Asperglaucide

Asperglaucide is an amide originally isolated from P. aurantiacum that has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties. Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2 (PGE2, Cay-14010), and IL-1beta in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 µM, respectively). It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and Trolox equivalent antioxidant capacity (TEAC) assays (EC50s = 9.51-78.81 µg/ml). Asperglaucide decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model.Formal Name: N-[(1S)-1-[(acetyloxy)methyl]-2-phenylethyl]-alphaS-(benzoylamino)-benzenepropanamide. CAS Number: 56121-42-7. Synonyms: Aurantiamide Acetate. Molecular Formula: C27H28N2O4. Formula Weight: 444.5. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)COC(C)=O)=O)C3=CC=CC=C3. InChi Code: InChI=1S/C27H28N2O4/c1-20(30)33-19-24(17-21-11-5-2-6-12-21)28-27(32)25(18-22-13-7-3-8-14-22)29-26(31)23-15-9-4-10-16-23/h2-16,24-25H,17-19H2,1H3,(H,28,32)(H,29,31)/t24-,25-/m0/s1. InChi Key: VZPAURMDJZOGHU-DQEYMECFSA-N. Origin: Fungus/Aspergillus sp..