Arachidonoyl-N,N-dimethyl amide

Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 µM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 µM. Formal Name: N,N-dimethyl-5Z,8Z,11Z,14Z-eicosatetraenamide. CAS Number: 45280-17-9. Synonyms: Arachidonic Acid-N,N-dimethyl amide. Molecular Formula: C22H37NO. Formula Weight: 331.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: 0.1 M Na2CO3: 1 mg/ml, DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)N(C)C. InChi Code: InChI=1S/C22H37NO/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(24)23(2)3/h8-9,11-12,14-15,17-18H,4-7,10,13,16,19-21H2,1-3H3/b9-8-,12-11-,15-14-,18-17-. InChi Key: FCHAVFLICKAOOF-GKFVBPDJSA-N.