Apigenin-d5

Apigenin-d5 is an internal standard for the quantificaiton of apigenin (Cay-10010275) by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IkappaBalpha and down-regulates NF-kappaB levels in WEHI-231 cells. Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-4H-1-benzopyran-4-one-3,6,8-d3. CAS Number: 263711-74-6. Synonyms: [3,6,8,3',5'-d5]-Apigenin, Chamomile-d5, Flavone-d5, Versulin-d5. Molecular Formula: C15H5D5O5. Formula Weight: 275.3. Purity: >99% deuterated forms (d1-d5), =1% d0. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Sparingly Soluble. SMILES: OC1=C([2H])C(O)=C(C(C([2H])=C(C2=CC([2H])=C(O)C([2H])=C2)O3)=O)C3=C1[2H]. InChi Code: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H/i3D,4D,5D,6D,7D. InChi Key: KZNIFHPLKGYRTM-DKFMXDSJSA-N.