Antimycin A3

Antimycin A3 is a component of the antimycin A complex that is more polar than antimycin A1 (Cay-19433) and antimycin A2 (Cay-21997) but not antimycin A4 (Cay-21999). Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria). It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species. In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2Delta22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2Delta22) in an isothermal calorimetry assay.Formal Name: 2(or 3)-methyl-butanoic acid, (2R,3S,6S,7R,8R)-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-butyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester. CAS Number: 522-70-3. Synonyms: Blastomycin, NSC 58239. Molecular Formula: C26H36N2O9. Formula Weight: 520.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CC(C)CC(O[C@@H]([C@@H]1C)[C@H](C(O[C@@H]([C@@H](C(O1)=O)NC(C(C=CC=C2NC([H])=O)=C2O)=O)C)=O)CCCC)=O. InChi Code: InChI=1S/C26H36N2O9/c1-6-7-9-18-23(37-20(30)12-14(2)3)16(5)36-26(34)21(15(4)35-25(18)33)28-24(32)17-10-8-11-19(22(17)31)27-13-29/h8,10-11,13-16,18,21,23,31H,6-7,9,12H2,1-5H3,(H,27,29)(H,28,32)/t15-,16+,18-,21+,23+/m1/s1. InChi Key: PVEVXUMVNWSNIG-PDPGNHKXSA-N.