Amcinonide

Amcinonide is a synthetic corticosteroid. Topical administration of amcinonide reduces inflammation in rat models of carrageenan-induced plantar edema and air pouch granulomas (ID50s = 1.85 and 4.2 mg/kg, respectively).Formal Name: (11beta,16alpha)-21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione. CAS Number: 51022-69-6. Synonyms: CL 34,699. Molecular Formula: C28H35FO7. Formula Weight: 502.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 236.00 nm. SMILES: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(COC(C)=O)=O)OC6(CCCC6)O5)=C1. InChi Code: InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1. InChi Key: ILKJAFIWWBXGDU-MOGDOJJUSA-N.