ALC-0315

ALC-0315 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of severe acute respiratory coronavirus 2 (SARS-CoV-2) mRNA in ALC-0315-containing LNPs induces the production of IgG that binds to the SARS-CoV-2 receptor-binding domain (RBD) in rhesus macaques, with a boost in antigen-specific IgG geometric mean titers (GMT) seven and 14 days after a second dose. Formulations containing ALC-0315 have been used in the development of LNPs for the delivery of mRNA-based vaccines.Formal Name: 2-hexyl-decanoic acid, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester. CAS Number: 2036272-55-4. Molecular Formula: C48H95NO5. Formula Weight: 766.3. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: 50 mg/ml, Ethanol: 50 mg/ml. SMILES: OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O. InChi Code: InChI=1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3. InChi Key: QGWBEETXHOVFQS-UHFFFAOYSA-N.