AL-A12

AL-A12 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing AL-A12 and encapsulating minicircle DNA that encodes for GFP have been used to induce GFP expression in Huh7 cells. LNPs containing AL-A12 and encapsulating DNA that encodes for RFP have been used to induce RFP expression in endothelial cells and venous vasculature in a zebrafish embryo model.Formal Name: N-dodecyl-N-(3-methoxypropyl)dodecan-1-amine. Molecular Formula: C28H59NO. Formula Weight: 425.8. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 10 mg/ml. SMILES: CCCCCCCCCCCCN(CCCOC)CCCCCCCCCCCC. InChi Code: InChI=1S/C28H59NO/c1-4-6-8-10-12-14-16-18-20-22-25-29(27-24-28-30-3)26-23-21-19-17-15-13-11-9-7-5-2/h4-28H2,1-3H3. InChi Key: XIJJLFBIFPWYLH-UHFFFAOYSA-N.