AH 23848 (calcium salt)

Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH 23848 is a dual antagonist of TP and EP4 receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 µM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH 23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4. By inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, and the proliferation of fibroblasts, as well as reduces metastasis in a mouse model of metastatic breast cancer.Formal Name: (4Z)-rel-7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid, hemicalcium salt. CAS Number: 81496-19-7. Molecular Formula: C29H34NO5 . 1/2Ca. Formula Weight: 496.6. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: > 5mg/ml. lambdamax: 254 nm. SMILES: O=C1C[C@H](OCC2=CC=C(C3=CC=CC=C3)C=C2)[C@H](CC/C=C\CCC([O-])=O)[C@H]1N4CCOCC4.O=C5C[C@H](OCC6=CC=C(C7=CC=CC=C7)C=C6)[C@H](CC/C=C\CCC([O-])=O)[C@H]5N8CCOCC8.[Ca+2]. InChi Code: InChI=1S/2C29H35NO5.Ca/c2*31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30,/h2*1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33),/q,,+2/p-2/b2*2-1-,/t2*25-,27-,29+,/m00./s1. InChi Key: JDEBIDDIERGZQY-KFZBTSSDSA-L.