Acemetacin

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of indomethacin (Cay-70270). It reduces zymosan-induced thromboxane B2 (TXB2, Cay-19030) and prostaglandin E2 (PGE2, Cay-14010) production in isolated rat whole blood and stomach, respectively, when administered at doses ranging from 2.7 to 83.8 µmol/kg. Acemetacin (1.3, 2.5, and 10 mg/kg) also reduces carrageenan-induced PGE2 production in rat synovial membranes. It decreases leukocyte infiltration in the exudate in a rat model of zymosan-induced air pouch inflammation when administered at doses of 27.9 and 83.8 µmol/kg.Formal Name: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, carboxymethyl ester. CAS Number: 53164-05-9. Molecular Formula: C21H18ClNO6. Formula Weight: 415.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: CC1=C(CC(OCC(O)=O)=O)C2=C(C=CC(OC)=C2)N1C(C3=CC=C(Cl)C=C3)=O. InChi Code: InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25). InChi Key: FSQKKOOTNAMONP-UHFFFAOYSA-N.