A17

A17 is a bile acid derivative. It reduces triglyceride accumulation induced by oleic acid (Cay-90260, Cay-24659), increases cell viability, and decreases oleic acid-induced lipid peroxidation in primary rat hepatocytes when used at concentrations of 10 and 25 µM. A17 (25 µM) reduces levels of CD36, also known as scavenger receptor B2 or fatty acid translocase, in primary rat hepatocytes. In vivo, A17 (50 mg/kg) reduces serum triglyceride, total cholesterol, and LDL levels, reverses hepatic steatosis, and decreases hepatic triglyceride, but not total cholesterol, levels in a hamster model of high-fat diet-induced non-alcoholic steatohepatitis (NASH).Formal Name: (3alpha,5beta,7beta)-3,7-bis(formyloxy)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-cholan-24-amide. CAS Number: 2568186-47-8. Molecular Formula: C31H51NO6. Formula Weight: 533.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Sparingly soluble: 1-10 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml. SMILES: O=CO[C@@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@@H](CCC(N[C@H](CO)C(C)C)=O)C)C)([H])[C@@]4([C@](C[C@@H](CC4)OC=O)([H])C1)C. InChi Code: InChI=1S/C31H51NO6/c1-19(2)26(16-33)32-28(36)9-6-20(3)23-7-8-24-29-25(11-13-31(23,24)5)30(4)12-10-22(37-17-34)14-21(30)15-27(29)38-18-35/h17-27,29,33H,6-16H2,1-5H3,(H,32,36)/t20-,21+,22-,23-,24+,25+,26-,27+,29+,30+,31-/m1/s1. InChi Key: RURKBKWBYCPAPK-WMDVUDLISA-N.