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C6 Ceramide (d18:1/6:0)
Item number: Cay62525-5
C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein...
| Keywords: | C6 Ceramide, Cer(18:1/6:0), Ceramide (d18:1/6:0), N-Caproyl-C18-sphingosine, N-hexanoyl-D-erythro-sphingosine,... |
| Application: | Bioactive lipid assays |
| CAS | 124753-97-5 |
| MW: | 397.6 D |
From 29.00€
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C24 Ceramide (d18:1/24:0)
Item number: Cay62535-25
Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of PLC, appropriately named sphingomyelinase. C24 Ceramide (d18:1/24:0) is one of the most abundant naturally occurring ceramides. Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing...
| Keywords: | C24 Ceramide, Cer(d18:1/24:0), Ceramide (d18:1/24:0), Lignoceric Ceramide, N-Lignoceroyl-D-erythro-Sphingosine,... |
| Application: | Bioactive lipid assays |
| CAS | 34435-05-7 |
| MW: | 650.1 D |
From 37.00€
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CAY10444
Item number: Cay10005033-5
CAY10444 is a sphingosine-1-phosphate receptor 3 (S1P3) antagonist. It inhibits S1P-induced calcium mobilization in CHO cells expressing human S1P3 (IC50 = 11.6 µM). CAY10444 (5 µM) inhibits S1P-induced growth and migration of MH7A rheumatoid fibroblast-like synoviocyte cells. It inhibits the localization and...
| Keywords: | BML-241, 2-undecyl-thiazolidine-4-carboxylic acid |
| Application: | S1P3 receptor antagonist |
| CAS | 298186-80-8 |
| MW: | 287.5 D |
From 84.00€
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(±)12-HpETE
Item number: Cay10138-25
(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Cay-90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Cay-34550). The biological activity of...
| Keywords: | 12-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 71030-35-8 |
| MW: | 336.5 D |
From 105.00€
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Ramatroban
Item number: Cay10156-5
Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619...
| Keywords: | Ramatroban, 3R-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid |
| Application: | DP2 receptor antagonist |
| CAS | 116649-85-5 |
| MW: | 416.5 D |
From 51.00€
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Menaquinone 4
Item number: Cay18423-100
Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain. It is formed primarily via conversion of vitamin K1 (Cay-21051) in vivo and accumulates in various tissues, including the brain. MK-4 halts the cell cycle at the G...
| Keywords: | MK-4, Vitamin K2(20), 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione |
| Application: | Vitamin K2 |
| CAS | 863-61-6 |
| MW: | 444.7 D |
From 62.00€
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Cholic Acid
Item number: Cay20250-50
Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA, Cay-20276) and...
| Keywords: | Cholalic Acid, Cholalin, NSC 6135, (5beta)-3alpha,7alpha,12alpha-trihydroxy-cholan-24-oic acid |
| Application: | Major primary bile acid |
| CAS | 81-25-4 |
| MW: | 408.6 D |
From 74.00€
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Deoxycholic Acid
Item number: Cay20756-5
Deoxycholic acid (DCA) is a secondary bile acid that is formed via microbial transformation of cholic acid (Cay-20250) in the colon. It can be conjugated to glycine or taurine (Cay-27031) to produce glycodeoxycholic acid (GDCA, Cay-20274) or taurodeoxycholic acid (TDCA, Cay-15935), respectively, in hepatocytes. DCA...
| Keywords: | Cholanoic Acid, DCA, NSC 8797, (3alpha,5beta,12alpha)-3,12-dihydroxy-cholan-24-oic acid |
| Application: | Secondary bile acid |
| CAS | 83-44-3 |
| MW: | 392.6 D |
From 30.00€
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Glycocholic Acid-d4
Item number: Cay21889-1
Glycocholic acid-d4 is intended for use as an internal standard for the quantification of glycocholic acid (Cay-20276) by GC- or LC-MS. Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid (Cay-20250) and has roles in the emulsification of fats. It reduces expression of the gene...
| Keywords: | Cholylglycine-d4, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine |
| Application: | Control |
| CAS | 1201918-15-1 |
| MW: | 469.7 D |
From 164.00€
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CDDO
Item number: Cay81035-1
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-gamma-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of...
| Keywords: | Bardoxolone, RTA 401, 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid |
| Application: | PPAR gamma ligand |
| CAS | 218600-44-3 |
| MW: | 491.7 D |
From 97.00€
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5(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester
Item number: Cay9000215-1
Mead acid is a 20-carbon omega-9 polyunsaturated fatty acid. Its level is elevated in plasma during essential fatty acid deficiency in humans. 5(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester (Mead acid methyl ester) is typically used as a standard for the analysis of fatty acids, when the fatty acids have been...
| Keywords: | Mead Acid methyl ester, 5Z,8Z,11Z-eicosatrienoic acid, methyl ester |
| Application: | Standard |
| CAS | 14602-39-2 |
| MW: | 320.5 D |
From 62.00€
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5-trans-17-phenyl trinor Prostaglandin F2alpha ethyl amide
Item number: Cay10008132-10
17-phenyl trinor Prostaglandin F2alpha (PGF2alpha) ethyl amide is an F-series PG analog which has been approved for use as an ocular hypotensive drug. 5-trans-17-phenyl trinor PGF2alpha ethyl amide is an isomer of 17-phenyl trinor PGF2alpha ethyl amide wherein the double bond between carbons 5 and 6 has been changed...
| Keywords: | 5,6-trans-17-phenyl trinor PGF2alpha ethyl amide, 5-trans Bimatoprost,... |
| Application: | Bioactive lipid assays |
| CAS | 1163135-95-2 |
| MW: | 415.6 D |
From 105.00€
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