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Myriocin
Item number: Cay63150-5
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the...
| Keywords: | ISP-1, Thermozymocidin, 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid |
| Application: | Serine palmitoyltransferase inhibitor |
| CAS | 35891-70-4 |
| MW: | 401.5 D |
From 53.00€
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alpha-Linolenic Acid
Item number: Cay90210-50
alpha-Linolenic acid (ALA) is an essential omega-3 polyunsaturated fatty acid found in plants. It is converted to the longer-chain fatty acids eicosapentaenoic (Cay-90110, Cay-90110.1, Cay-21908), docosapentaenoic (Cay-90165, Cay-21907), and docosahexaenoic acid (Cay-90310). It is also catabolized via fatty acid...
| Keywords: | ALA, C18:3 (9Z,12Z,15Z), C18:3 n-3, 9Z,12Z,15Z-octadecatrienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 463-40-1 |
| MW: | 278.4 D |
From 44.00€
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Arachidonic Acid (peroxide free)
Item number: Cay90010.1-100
Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
| Keywords: | AA (peroxide free), 5Z,8Z,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 506-32-1 |
| MW: | 304.5 D |
From 68.00€
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12(S)-HETE-d8
Item number: Cay334570-25
12(S)-HETE-d8 is intended for use as an internal standard for the quantification of 12-HETE by GC- or LC-MS. (±)12-HETE is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 12(S)- and 12(R)-HETE are formed by 12(S)- and 12(R)-lipoxygenase-mediated oxidation of arachidonic...
| Keywords: | 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 84807-90-9 |
| MW: | 328.5 D |
From 281.00€
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12(S)-HETE
Item number: Cay34570-25
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.Formal Name: 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid. CAS Number: 54397-83-0. Synonyms: 12(S)-Hydroxyeicosatetraenoic Acid....
| Keywords: | 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 54397-83-0 |
| MW: | 320.5 D |
From 221.00€
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Dihomo-gamma-Linolenic Acid
Item number: Cay90230-10
Dihomo-gamma-Linolenic Acid (DGLA, 20:3), an elongation product of gamma-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1. In mice, DGLA supplementation...
| Keywords: | cis-8,11,14-Eicosatrienoic Acid, DGLA, gamma-Homolinolenic Acid, 8Z,11Z,14Z-eicosatrienoic acid |
| Application: | LTB4 receptor antagonist |
| CAS | 1783-84-2 |
| MW: | 306.5 D |
From 53.00€
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N-3-oxo-dodecanoyl-L-Homoserine lactone
Item number: Cay10007895-1
N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex. It induces the production of IL-8 in 16HBE human bronchial epithelial cells when used at a concentration of 100 µM. Supernatants from...
| Keywords: | 3-oxo-C12-HSL, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-dodecanamide |
| Application: | Bioactive lipid assays |
| CAS | 168982-69-2 |
| MW: | 297.4 D |
From 50.00€
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(±)12(13)-DiHOME
Item number: Cay10009832-100
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME (Cay-52450), a cytochrome P450-derived epoxide of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) also known as isoleukotoxin. It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. 12(13)-DiHOME is toxic to Sf21 cells expressing sEH...
| Keywords: | Isoleukotoxin diol, 12,13-dihydroxy-9Z-octadecenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 263399-35-5 |
| MW: | 314.5 D |
From 68.00€
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Maresin 1
Item number: Cay10878-10
Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in...
| Keywords: | 7(R)-MaR1, 7(R)-Maresin 1, 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid |
| Application: | Inflammation studies |
| CAS | 1268720-28-0 |
| MW: | 360.5 D |
From 118.00€
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Palmitic Acid
Item number: Cay10006627-10
Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively. Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid...
| Keywords: | C16:0, hexadecanoic acid |
| Application: | Bioactive lipid assays |
| CAS | 57-10-3 |
| MW: | 256.4 D |
From 60.00€
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(±)19(20)-EpDPA
Item number: Cay10175-500
(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not...
| Keywords: | (±)19,20 EDP, (±)19,20-EpDPE, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA,... |
| Application: | CYP450 metabolism studies |
| MW: | 344.5 D |
From 68.00€
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12-oxo Phytodienoic Acid
Item number: Cay88520-1
12-oxo Phytodienoic acid (OPDA) is a biologically active, immediate precursor of 7-epi jasmonic acid. In addition to its link with jasmonic acid activity, OPDA appears to play an independent role in mediating resistance to pathogens and pests. As an endogenous signal transducer, OPDA has been shown to increase...
| Keywords: | 12-oxo PDA, OPDA, 4-oxo-5alpha-2Z-pentenyl)-2-cyclopentene-1alpha-octanoic acid |
| Application: | Bioactive lipid assays |
| CAS | 85551-10-6 |
| MW: | 292.4 D |
From 127.00€
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