No results were found for the filter!
4-O10b1
Item number: Cay40603-10
An ionizable cationic lipid (pKa = 5.148), LNPs containing 4-O10b1, conjugated to an anti-F4/80 antibody, and encapsulating siRNA targeting the mRNA encoding Tak1 inhibit poly(I:C)-induced production of IL-1beta, IL-6, and TNF-alpha in RAW 264.7 macrophages, intranasal administration of these LNPs decreases lung...
| Keywords: | tetra(decan-2-yl) 3,3',3'',3'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1049.7 D |
From 116.00€
*
1,2-Dierucoyl-sn-glycero-3-PE
Item number: Cay41090-10
A phospholipid, has been used in the generation of LNPs for the delivery of mRNA in vivo, has been used in the synthesis of various PEG-conjugates for incorporation into liposomes, LNPs containing 1,2-dierucoyl-sn-glycero-3-PE and encapsulating mRNA encoding hEPO increase serum hEPO levels in mice. Formulation: A...
| Keywords: | 1,2-Didocosenoyl-sn-glycero-3-Phosphoethanolamine, 22:1/22:1-PE, di22:1-PE, PE(22:1/22:1), (13Z,13'Z)-13-docosenoic acid,... |
| Application: | Phospholipid, LNP formation |
| CAS | 904304-57-0 |
| MW: | 856.3 D |
From 55.00€
*
1-1(Z)-Hexadecenyl-2-hydroxy-sn-glycero-3-PC
Item number: Cay41465-1
A lysoplasmalogen, increases the lag phase of a-synuclein aggregation in a cell-free assay. Formulation: A solid. InChI: InChI=1S/C24H50NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h18,20,24,26H,5-17,19,21-23H2,1-4H3/b20-18-/t24-/m1/s1. InChIKey:...
| Keywords: | 16:0p/0:0-PC, C16:0(plasm)-0:0-PC, 4-oxide, 4,7-dihydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacos-10-en-1-aminium,... |
| Application: | Lysoplasmalogen |
| CAS | 97802-53-4 |
| MW: | 479.63 D |
From 153.00€
*
1-1(Z)-Octadecenyl-2-hydroxy-sn-glycero-3-PE
Item number: Cay41466-1
A lysoplasmalogen, increases intracellular levels of cAMP, mitochondrial OCR, basal and maximal respiration, and ATP production in C3H/10T1/2 cells at 10 µM, reduces blood levels of glucose in an intraperitoneal GTT in mice fed a high-fat diet at 200 µg/kg per day, serum levels are reduced in patients with...
| Keywords: | 1-1(Z)-Octadecenyl-2-hydroxy-sn-glycero-3-phosphoethanolamine, 18p/0:0-PE, C18(plasm)-0:0-PE, LPE P-18:0, PE(P-18:0/0:0),... |
| Application: | Lysoplasmalogen |
| CAS | 174062-73-8 |
| MW: | 465.6 D |
From 214.00€
*
DOSEH (chloride)
Item number: Cay41601-10
A cationic sulfonium lipid, has been used in the generation of sLNPs for the delivery of mRNA in vivo, LNPs containing DOSEH and encapsulating an mRNA reporter accumulate primarily in the lungs after intravenous administration in mice, DOSEH-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in...
| Keywords: | (2-hydroxyethyl)dioctadecylsulfonium, monochloride |
| Application: | Cationic sulfonium lipid, LNP formation |
| MW: | 619.6 D |
From 197.00€
*
Campesterol
Item number: Cay41695-1
A phytosterol with diverse biological activities, inhibits basic FGF-induced proliferation in, and vessel formation by, HUVECs at 1, 5, or 10 µM., decreases the proliferation of MCF-7 and ZR-75-1 cells at 15 µM, reduces the levels of ERalpha in, and the diameter of, patient-derived breast cancer organoids at 10 µM,...
| Keywords: | Campesterin, NSC 224330, (3beta,24R)-ergost-5-en-3-ol |
| Application: | Bioactive phytosterol |
| CAS | 474-62-4 |
| MW: | 400.68 D |
From 45.00€
*
CP-LC-1428
Item number: Cay41924-10
Lipid CP-LC-1428 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG:...
| Keywords: | 6-methylheptyl... |
| Application: | Ionizable cationic amino lipid, homocysteine derivative |
| MW: | 1004.58 D |
From 229.00€
*
Lipid 12T-O14
Item number: Cay41946-1
An amidine-incorporated degradable lipid (pKa 8.15), has been used in the generation of LNPs for the delivery of siRNA and mRNA in vitro or in vivo, LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells, intramuscular delivery of LNPs containing lipid 12T-O14 and...
| Keywords: | tetradecyl 3-((4-((4-decylphenyl)amino)-4-iminobutyl)thio)propanoate |
| Application: | Amidine-incorporated degradable lipid, LNP formation |
| MW: | 603 D |
From 116.00€
*
N-Lithocholyl-L-Alanine
Item number: Cay40929-100
A bile acid conjugate and an EPHA2 inhibitor (IC50 = 19.95 µM). Formulation: A solid. InChI: InChI=1S/C27H45NO4/c1-16(5-10-24(30)28-17(2)25(31)32)21-8-9-22-20-7-6-18-15-19(29)11-13-26(18,3)23(20)12-14-27(21,22)4/h16-23,29H,5-15H2,1-4H3,(H,28,30)(H,31,32)/t16-,17+,18-,19-,20+,21-,22+,23+,26+,27-/m1/s1. InChIKey:...
| Keywords: | N-[(3a,5beta)-3-hydroxy-24-oxocholan-24-yl]-L-alanine |
| Application: | Bile acid conjugate, EPHA2 inhibitor |
| CAS | 1428095-28-6 |
| MW: | 447.65 D |
From 110.00€
*
DMT7
Item number: Cay41389-1
An ionizable cationic lipid (pKa = 6.5), has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo, LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast...
| Keywords: | 1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 658.2 D |
From 105.00€
*
Lipid A
Item number: Cay41708-1
An ionizable cationic lipid (pKa = 4.67). Formulation: A solution in ethanol. InChI: InChI=1S/C48H95NO5/c1-6-11-15-19-21-29-37-44(35-27-17-13-8-3)47(51)53-41-33-25-23-31-39-49(46(10-5)43-50)40-32-24-26-34-42-54-48(52)45(36-28-18-14-9-4)38-30-22-20-16-12-7-2/h44-46,50H,6-43H2,1-5H3. InChIKey:...
| Keywords: | 2-hexyl-decanoic acid, 1,1'-[[[1-(hydroxymethyl)propyl]imino]di-6,1-hexanediyl] ester |
| Application: | Ionizable cationic lipid |
| CAS | 2036273-20-6 |
| MW: | 766.27 D |
From 120.00€
*
O12-D3-I3
Item number: Cay41385-1
An ionizable cationic lipid (pKa = 6.39), has been used in the generation of LNPs for siRNA delivery in vitro and in vivo, LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells, LNPs containing O12-D3-I3 and an...
| Keywords: | didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 692.03 D |
From 60.00€
*