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306-O12B
Item number: Cay37549-10
306-O12B is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9...
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Ionizable cationic lipidoid, LNP formation |
| CAS | 2566523-06-4 |
| MW: | 1251.09 D |
From 162.00€
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113-O12B
Item number: Cay37671-10
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing...
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Cationic lipidoid, LNP generation |
| CAS | 2803699-72-9 |
| MW: | 1223 D |
From 193.00€
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GK241
Item number: Cay37689-1
GK241 is a secretory phospholipase A2 (sPLA2) (Type IIA) inhibitor (IC50s = 0.143 and 0.068 µM for the human and mouse enzymes, respectively). It inhibits IL-1beta-induced production of prostaglandin E2 (PGE2, Cay-14010) in isolated rat renal mesangial cells when used at concentrations of 3 and 10 µM. GK241 also...
| Keywords: | N-(1,2-dioxohexadecyl)-L-valine |
| Application: | sPLA2 (type IIA) inhibitor |
| CAS | 1899930-93-8 |
| MW: | 369.5 D |
From 87.00€
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Cholesteryl Linoleate-d11
Item number: Cay37920-100
Cholesteryl linoleate-d11 is intended for use as an internal standard for the quantification of cholesteryl linoleate (Cay-22597) by GC- or LC-MS. Cholesteryl linoleate is a pro-atherogenic cholesterol ester. It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation...
| Keywords: | 18:2(9Z,12Z)-d11 CE, C18:2(9Z,12Z)-d11 Cholesteryl ester, CE(18:2)-d11, Cholest-5-en-3beta-yl... |
| Application: | GC-MS, LC-MS internal standard, quantification, pro-atherogenic cholesterol ester |
| MW: | 660.2 D |
From 55.00€
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Heptadecanoyl-L-carnitine (chloride)
Item number: Cay37934-1
Heptadecanoyl-L-carnitine is a long-chain acylcarnitine composed of heptadecanoic acid (Cay-19722) and L-carnitine (Cay-21489). Levels of heptadecanoyl-L-carnitine are increased in dried blood spots from neonates with propionic or methylmalonic acidemias, inborn errors of metabolism characterized by a deficiency in...
| Keywords: | C17:0 Carnitine, CAR 17:0, L-Carnitine heptadecanoyl ester, L-Heptadecanoylcarnitine,... |
| Application: | Long-chain acylcarnitine |
| CAS | 173686-69-6 |
| MW: | 450.1 D |
From 157.00€
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Eicosapentaenoic Acid-d5 ethyl ester
Item number: Cay37972-100
Eicosapentaenoic acid-d5 ethyl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester (Cay-10008884) by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the omega-3 fatty acid EPA (Cay-90110, Cay-90110.1, Cay-21908). Dietary...
| Keywords: | EPA-d5 ethyl ester, 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic-19,19,20,20,20-d5 acid, ethyl ester |
| Application: | GC-MS, LC-MS internal standard, quantification, eicosapentaenoic acid ethyl ester |
| CAS | 2483831-19-0 |
| MW: | 335.5 D |
From 174.00€
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A12-Iso5-2DC18
Item number: Cay38586-1
A12-Iso5-2DC18 is an ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing A12-Iso5-2DC18 and encapsulating mRNA encoding luciferase have been used to induce luciferase expression in HeLa cells.Formal Name:...
| Keywords: | 1-[3-(dimethylamino)propyl]-5,5-di-(8Z)-8-heptadecen-1-yl-2,5-dihydro-1H-imidazole-2-carboxylic acid, ethyl ester |
| Application: | Ionizable cationic lipidoid, LNP formation |
| CAS | 2412492-06-7 |
| MW: | 700.2 D |
From 134.00€
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1-Myristyl-2-hydroxy-sn-glycero-3-PA
Item number: Cay9001408-1
1-Myristyl-2-hydroxy-sn-glycero-3-PA (1-myristyl LPA) is an LPA derivative containing myristic acid (Cay-13351) at the sn-1 position and agonist of lysophosphatidic acid receptor 1 (LPA1) and LPA2. It increases calcium mobilization in a reporter assay using HEL 92.1.7 cells (EC50 = 37 nM).Formal Name:...
| Keywords: | 14:0 Lyso PA, 1-Myristyl LPA, 1-Myristyl-sn-glycero-3-phosphate, 1-Tetradecyl-sn-glycero-3-phosphate, LPA(14:0),... |
| Application: | LPA derivative, LPA1 and LPA2 agonist |
| MW: | 368.5 D |
From 42.00€
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Prostaglandin A2 ethyl ester
Item number: Cay9002816-1
Prostaglandin A2 (PGA2) ethyl ester is an ester form of PGA2 (Cay-10210).Formal Name: ethyl (Z)-7-((1R,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)hept-5-enoate. Synonyms: PGA2 ethyl ester. Molecular Formula: C22H34O4. Formula Weight: 362.5. Purity: >95%. Formulation: (Request formulation change),...
| Keywords: | PGA2 ethyl ester, ethyl (Z)-7-((1R,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)hept-5-enoate |
| Application: | PGA2 ester form |
| MW: | 362.5 D |
From 104.00€
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15(S)-15-methyl Prostaglandin F2alpha ethyl amide
Item number: Cay10010064-1
15(S)-15-methyl Prostaglandin F2alpha has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2alpha ethyl amide is a lipophilic analog of 15(S)-15-methyl PGF2alpha methyl ester. Prostaglandin esters are generally hydrolyzed...
| Keywords: | 15(S)-15-methyl PGF2alpha ethyl amide, 9alpha,11alpha,15S-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid, ethyl amide |
| Application: | Lipophilic 15(S)-15-methyl PGF2alpha methyl ester analog |
| MW: | 395.6 D |
From 134.00€
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Tomatine
Item number: Cay16024-10
Tomatine is a steroidal saponin that has been found in S. lycopersicum and has diverse biological activities. It is active against a panel of 19 plant pathogenic fungi (EC50s = 13-912 µM) and inhibits the growth of L. amazonensis promastigotes (IC50 = 124 nM). Tomatine (0.75, 1, and 1.5 µM) inhibits autophagy and...
| Keywords: | Lycopersicin, NSC 234440, NSC 9223, alpha-Tomatine, (3beta,5alpha,22beta,25S)-spirosolan-3-yl... |
| Application: | Bioactive steroidal saponin |
| CAS | 17406-45-0 |
| MW: | 1034.2 D |
From 89.00€
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16-phenyl tetranor Prostaglandin F2alpha
Item number: Cay16770-1
16-phenyl tetranor Prostaglandin F2alpha (16-phenyl tetranor PGF2alpha) is a metabolically stable analog of PGF2alpha. The affinity of 16-phenyl tetranor PGF2alpha at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2alpha.Formal Name:...
| Keywords: | 16-phenyl tetranor PGF2alpha,... |
| Application: | Stable PGF2alpha analog |
| CAS | 38315-48-9 |
| MW: | 374.5 D |
From 93.00€
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