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Dehydroepiandrosterone Sulfate 17-(O-carboxymethyl)oxime...
Item number: Cay35658-10
Dehydroepiandrosterone sulfate 17-(O-carboxymethyl)oxime is a derivative of dehydroepiandrosterone sulfate (Cay-15873).Formal Name: [[[(3beta)-3-(sulfooxy)androst-5-en-17-ylidene]amino]oxy]-acetic acid, monosodium salt. Synonyms: DHA-S 17-(O-carboxymethyl)oxime, DHEAS 17-(O-carboxymethyl)oxime. Molecular Formula:...
| Keywords: | DHA-S 17-(O-carboxymethyl)oxime, DHEAS 17-(O-carboxymethyl)oxime,... |
| Application: | Dehydroepiandrosterone sulfate derivative |
| MW: | 464.5 D |
From 47.00€
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Crebanine
Item number: Cay36176-1
Crebanine is an aporphine alkaloid that has been found in Stephania venosa and has diverse biological activities. It is an antagonist of alpha7 nicotinic acetylcholine receptors (nAChRs, IC50 = 19.1 µM) and inhibits sodium currents (INa) in isolated guinea pig ventricular myocytes (IC50 = 283 µM). Crebanine is...
| Keywords: | (-)-Crebanine, (7R)-6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline |
| Application: | Aporphine alkaloid |
| CAS | 25127-29-1 |
| MW: | 339.4 D |
From 76.00€
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1O14
Item number: Cay38150-10
1O14 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). 1O14-containing LNPs have been used for the delivery of IL-1beta siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury induced by LPS...
| Keywords: | 15,19,28-tris(2-hydroxytetradecyl)-15,19,24,28-tetraazadotetracontane-13,30-diol |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1264.2 D |
From 157.00€
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YK-009
Item number: Cay38282-1
YK-009 is an ionizable cationic lipid (pKa = 6.512) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant mRNA in YK-009-containing LNPs induces the production of IgG that...
| Keywords: | 6-[[4-(decyloxy)-4-oxobutyl](2-hydroxyethyl)amino]-hexanoic acid, 2-octyldecyl ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2761458-86-8 |
| MW: | 654.1 D |
From 115.00€
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1-Arachidoyl-2-hydroxy-sn-glycero-3-PC
Item number: Cay38303-10
1-Arachidoyl-2-hydroxy-sn-glycero-3-PC is a lysophospholipid containing arachidic acid (Cay-9000339, Cay-21906) at the sn-1 position. Plasma levels of 1-arachidoyl-2-hydroxy-sn-glycero-3-PC are increased in ApoE-/- mice fed a high-fat diet.Formal Name:...
| Keywords: | 1-Eicosanoyl-sn-glycero-3-Phosphatidylcholine, 1-Eicosanoyl-sn-glycero-3-Phosphocholine, 20:0 Lyso-PC, 20:0/0:0-PC,... |
| Application: | Lysophospholipid |
| CAS | 108341-80-6 |
| MW: | 551.7 D |
From 57.00€
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1-Linoleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)
Item number: Cay38309-1
1-Linoleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) (1-linoleoyl LPA) is an agonist of the LPA2 receptor and a glycerophospholipid containing linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) at the sn-1 position. It is the most abundant LPA in mouse and human plasma. 1-Linoleoyl LPA selectively increases...
| Keywords: | PA(18:2(9Z,12Z)/0:0), 18:2 Lyso PA, 1-Linoleoyl LPA, 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,... |
| Application: | LPA2 receptor agonist, glycerophospholipid |
| CAS | 72777-86-7 |
| MW: | 434.5 D |
From 104.00€
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Prostaglandin E2 Inhibitor 3
Item number: Cay38316-1
Prostaglandin E2 (PGE2) inhibitor 3 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1, IC50 = 0.2 µM). It is selective for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH) in cell-free assays at 10 µM. PGE2 inhibitor 3 inhibits IL-1beta-induced production of PGE2...
| Keywords: | PGE2 Inhibitor 3, 2-bromo-N-(5-(3'-hydroxy-[1,1'-biphenyl]-4-yl)-1,3,4-thiadiazol-2-yl)benzamide |
| Application: | Microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor |
| MW: | 452.3 D |
From 95.00€
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Lipid 14
Item number: Cay38589-10
Lipid 14 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing lipid 14 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface...
| Keywords: | ((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate) |
| Application: | Ionizable cationic amino lipid, LNP formation |
| CAS | 2430034-05-0 |
| MW: | 907.5 D |
From 423.00€
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UT-11
Item number: Cay38580-1
UT-11 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It inhibits PGE2 production in both SK-N-AS human neuroblastoma and BV-2 mouse microglial cells (IC50s = 0.1 and 2 µM, respectively). UT-11 (10 mg/kg, i.p.) reduces LPS-induced increases in a variety of cytokines, including chemokine (C-C...
| Keywords: | (R)-1-(5,6-dichlorobenzo[d]thiazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide |
| Application: | Microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor |
| MW: | 400.3 D |
From 76.00€
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AA-T3A-C12
Item number: Cay38648-1
AA-T3A-C12 is an ionizable cationic lipidoid that contains a polyamine core, tethered to the sigma receptor ligand anisamide, and four 12-carbon tails. It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing AA-T3A-C12 and encapsulating siRNA for Hsp47, a molecular chaperone whose...
| Keywords: | N-(3-(bis(3-(bis(2-hydroxydodecyl)amino)propyl)amino)propyl)-4-methoxybenzamide |
| Application: | Ionizable cationic lipidoid, LNP formation |
| MW: | 1059.7 D |
From 115.00€
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Lipid Catechol
Item number: Cay38665-1
Lipid catechol is a lipid that contains an alpha-aminophosphonate group, two 14-carbon acyl chains, and a catechol ring that forms a covalent bond with boronic acid-containing compounds to form lipid prodrug nanoassemblies (LPNA). LPNAs composed of lipid catechol conjugated to phenylboronic acid-modified...
| Keywords: | ditetradecyl (((2-(diethylamino)ethyl)amino)(3,4-dihydroxyphenyl)methyl)phosphonate |
| Application: | Lipid, LPNA (lipid prodrug nanoassembly) formation |
| MW: | 711.1 D |
From 134.00€
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Lipid 8
Item number: Cay38746-10
Lipid 8 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). LNPs containing lipid 8 and encapsulating polo-like kinase 1 (Plk1) siRNA induce apoptosis in U266 multiple myeloma cells.Formal Name: 4-(dimethylamino)-butanoic acid,...
| Keywords: | 4-(dimethylamino)-butanoic acid, 2-[di-(9Z,12Z)-9,12-octadecadien-1-ylamino]ethyl ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2226547-25-5 |
| MW: | 671.1 D |
From 234.00€
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