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(±)8(9)-EET
Item number: Cay50351-50
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by...
| Keywords: | (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| MW: | 320.5 D |
From 60.00€
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Lipid-based Drug Delivery Tools
Sphingosine-1-phosphate (d18:1)
Item number: Cay62570-1
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
| Keywords: | S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Application: | Bioactive lipid assays |
| CAS | 26993-30-6 |
| MW: | 379.5 D |
From 122.00€
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Prostaglandin D2
Item number: Cay12010-1
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
| Keywords: | PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 41598-07-6 |
| MW: | 352.5 D |
From 85.00€
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(±)14(15)-EET
Item number: Cay50651-50
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary...
| Keywords: | (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 197508-62-6 |
| MW: | 320.5 D |
From 85.00€
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Arachidonic Acid
Item number: Cay90010-100
Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
| Keywords: | AA, 5Z,8Z,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 506-32-1 |
| MW: | 304.5 D |
From 55.00€
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Prostaglandin F2alpha
Item number: Cay16010-10
Prostaglandin F2alpha (PGF2alpha) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF2alpha exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine...
| Keywords: | Dinoprost, PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 551-11-1 |
| MW: | 354.5 D |
From 70.00€
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(±)9-HODE
Item number: Cay38400-100
(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs...
| Keywords: | (±)-9-hydroxy-10E,12Z-octadecadienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 98524-19-7 |
| MW: | 296.5 D |
From 223.00€
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Resolvin D1
Item number: Cay10012554-10
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced...
| Keywords: | 17(S)-Resolvin D1, RvD1, 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 872993-05-0 |
| MW: | 376.5 D |
From 235.00€
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8-iso Prostaglandin F2alpha
Item number: Cay16350-1
8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha...
| Keywords: | 15-F2t-Isoprostane, 8-epi PGF2alpha, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, iPF2alpha-III,... |
| Application: | TP receptor agonist |
| CAS | 27415-26-5 |
| MW: | 354.5 D |
From 269.00€
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Fumonisin B1
Item number: Cay62580-5
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces...
| Keywords: | FB1, (2R,2'R)-1,2,3-propanetricarboxylic acid,... |
| Application: | Ceramide synthase inhibitor |
| CAS | 116355-83-0 |
| MW: | 721.8 D |
From 120.00€
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15-deoxy-Delta12,14-Prostaglandin J2
Item number: Cay18570-1
15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
| Keywords: | 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 87893-55-8 |
| MW: | 316.4 D |
From 55.00€
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Lipoxin A4
Item number: Cay90410-25
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several...
| Keywords: | 5(S),6(R),15(S)-TriHETE, LXA4, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 89663-86-5 |
| MW: | 352.5 D |
From 319.00€
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