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Sphingosine (d18:1)
Item number: Cay10007907-10
Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces...
| Keywords: | (-)-Sphingosine, D-erythro-Sphingosine C-18, 2S-amino-4E-octadecene-1,3R-diol |
| Application: | Bioactive lipid assays |
| CAS | 123-78-4 |
| MW: | 299.5 D |
From 61.00€
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(±)9(10)-DiHOME
Item number: Cay53400-25
(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Cay-52400), a cytochrome P450-derived epoxide of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) also known as leukotoxin. It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. It is toxic to Sf21 cells expressing sEH and to...
| Keywords: | Leukotoxin diol, (±)9,10-dihydroxy-12Z-octadecenoic acid |
| Application: | Cytotoxic agent |
| CAS | 263399-34-4 |
| MW: | 314.5 D |
From 44.00€
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Docosapentaenoic Acid
Item number: Cay90165-1
Docosapentaenoic acid is an omega-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.Formal Name: 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acid. CAS Number: 24880-45-3. Synonyms: DPA, n-3 DPA, FA...
| Keywords: | DPA, 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 24880-45-3 |
| MW: | 330.5 D |
From 44.00€
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5(S),15(S)-DiHETE
Item number: Cay35280-25
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 µM.Formal Name: 5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic...
| Keywords: | 5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 82200-87-1 |
| MW: | 336.5 D |
From 133.00€
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Prostaglandin E3
Item number: Cay14990-50
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.Formal Name:...
| Keywords: | PGE3, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 802-31-3 |
| MW: | 350.5 D |
From 193.00€
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9-cis Retinal
Item number: Cay21692-10
9-cis Retinal is a natural retinoid that is produced by oxidation of 9-cis retinol by cis-retinol dehydrogenase (cRDH). It binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 8 and 5 nM, respectively) and to cellular retinaldehyde-binding protein (CRALBP, Kd = 53.3 nM). In vitro, 9-cis retinal...
| Keywords: | 9-cis Retinaldehyde, 9-cis Vitamin A aldehyde, 9-cis-retinal |
| CAS | 514-85-2 |
| MW: | 284.4 D |
From 67.00€
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trans-Vaccenic Acid methyl ester
Item number: Cay26731-25
trans-Vaccenic acid methyl ester is an esterified form of trans-vaccenic acid (Cay-15301). It has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS.Formal Name: (11E)-11-octadecenoic acid, methyl ester. CAS Number: 6198-58-9. Synonyms: C18:1 methyl...
| Keywords: | trans-11-Octadecenoic Acid methyl ester, C18:1 methyl ester, Methyl trans-11-Octadecenoate, Methyl trans-Vaccenate,... |
| Application: | GC-MS, LC-MS, identification, quantification, standard, fatty acid methyl ester |
| CAS | 6198-58-9 |
| MW: | 296.5 D |
From 39.00€
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C9-200
Item number: Cay40862-1
C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing C9-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum EPO levels in mice. LNPs containing C9-200 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA)...
| Keywords: | 1,1'-((2-(4-(2-((2-(bis(2-hydroxynonyl)amino)ethyl)(2-hydroxynonyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(nonan-2-ol) |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 926.5 D |
From 40.00€
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Lipid N2-3L
Item number: Cay40911-1
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo. SMLNPs containing lipid N2-3L and encapsulating a luciferase reporter accumulate at the site of injection and in the draining...
| Keywords: | 9Z-octadecenoic acid,... |
| Application: | Ionizable cationic lipid, SMLNP generation |
| CAS | 2924606-55-1 |
| MW: | 840.3 D |
From 103.00€
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N-Lithocholyl-L-Leucine
Item number: Cay40931-1
N-Lithocholyl-L-leucine is a bile acid conjugate composed of lithocholic acid (Cay-20253) and L-leucine (Cay-34342). It has been used in the formation of hydrogels.Formal Name: N-[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl]-L-leucine. CAS Number: 2095154-73-5. Molecular Formula: C30H51NO4. Formula Weight: 489.7....
| Keywords: | N-[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl]-L-leucine |
| Application: | Bile acid conjugate, hydrogel formation |
| CAS | 2095154-73-5 |
| MW: | 489.7 D |
From 54.00€
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Q1-ALC-0315 (iodide)
Item number: Cay41240-1
Q1-ALC-0315 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (Cay-34337) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo. LNPs containing Q1-ALC-0315 and ALC-0315 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase...
| Keywords: | 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)-N-methylhexan-1-aminium, monoiodide |
| Application: | Ionizable cationic lipid ALC-0315 cationic quaternary ammonium lipid derivative, LNP formation |
| MW: | 908.2 D |
From 40.00€
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Lipid 7-1
Item number: Cay41304-1
Lipid 7-1 is an ionizable cationic lipid.Formal Name: 8-[[6-[4,4-bis[(5Z)-5-octen-1-yloxy]-1-oxobutoxy]hexyl](2-hydroxyethyl)amino]-octanoic acid, nonyl ester. CAS Number: 2795392-95-7. Molecular Formula: C45H85NO7. Formula Weight: 752.2. Purity: >98%. Formulation: (Request formulation change), A solution in...
| Keywords: | 8-[[6-[4,4-bis[(5Z)-5-octen-1-yloxy]-1-oxobutoxy]hexyl](2-hydroxyethyl)amino]-octanoic acid, nonyl ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2795392-95-7 |
| MW: | 752.2 D |
From 102.00€
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