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(R)-C12-200
Item number: Cay43647-10
(R)-C12-200 is an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200 (Cay-36699) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (R)-C12-200 and encapsulating mRNA encoding Cre recombinase increases the...
| Keywords: | KB-R12,... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 1226777-45-2 |
| MW: | 1136,96 D |
From 279.00€
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trans-Vaccenic Acid (sodium salt)
Item number: Cay44257-10
trans-Vaccenic acid is an omega-7 fatty acid that has been found in bovine milk fats. Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity...
| Keywords: | C18:1 n-7, C18:1(11E), FA 18:1, trans-11-Octadecenoic Acid, (11E)-11-octadecenoic acid, monosodium salt |
| Application: | omega-7 fatty acid |
| CAS | 104233-68-3 |
| MW: | 304,45 D |
From 53.00€
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Rosuvastatin (sodium salt)
Item number: Cay44550-100
Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...
| Keywords: | ZD 4522,... |
| Application: | HMG-CoA reductase inhibitor |
| CAS | 147098-18-8 |
| MW: | 503,52 D |
From 73.00€
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DSPE-PEG(2000)-tri-GalNAc
Item number: Cay44551-100
DSPE-PEG(2000)-tri-GalNAc is a multivalent N-acetylgalactosamine-conjugated lipid composed of an O-deacetylated derivative of LNP GalNAc ligand 1 (Cay-38952), a GABA linker, a PEG(2000) spacer, and 1,2-distearoyl-rac-glycero-3-phosphoethanolamine. Multivalent GalNAc-conjugated lipids have been used in the generation...
| Keywords: | 3-((((39-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-24,24-bis((3-((3-(5-(... |
| Application: | Multivalent GalNAc-conjugated lipid, LNP generation |
From 147.00€
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DSPE-PEG(2000)-DBCO
Item number: Cay44696-10
DSPE-PEG(2000)-DBCO is a PEGylated and clickable form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE, Cay-15095) that has been used in the formation of liposomes and lipid nanodiscs. It has been used in the generation of liposome-anchored macrophages for the delivery of a cholesterol-conjugated toll-like receptor 7/8...
| Keywords: | 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000],... |
| Application: | PEGylated, clickable DSPE form, liposomes/lipid nanodisc formation |
| CAS | 1895854-56-4 |
From 149.00€
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1-17(S)-HDHA-rac-glycerol
Item number: Cay9004367-100
1-17(S)-HDHA-rac-glycerol is a monoacylglycerol that contains 17(S)-HDHA (Cay-10009799). InChI: InChI=1S/C25H38O5/c1-2-3-15-18-23(27)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-25(29)30-22-24(28)21-26/h3,5-8,11-16,19,23-24,26-28H,2,4,9-10,17-18,20-22H2,1H3/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+/t23-,24?/m0/s1 InChIKey:...
| Keywords: | 1-17(S)-HDHE Glycerol, 1-17(S)-HDoHE Glycerol, 1-17(S)-hydroxy DHA Glycerol, 1-17(S)-hydroxy Docosahexaenoyl Glycerol,... |
| Application: | Monoacylglycerol |
| MW: | 418,6 D |
From 112.00€
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LPS from E. coli O55:B5 (S-form) TLRpure Sterile Solution
Item number: IAX-100-013-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
| Keywords: | Lipopolysaccharide (LPS) from E. coli O55:B5, S-type (smooth/wild-type) LPS |
| Application: | TLR4 activator |
From 288.00€
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1-Oleoyl-2-hydroxy-sn-glycero-3-PA
Item number: Cay10010093-5
1-Oleoyl-2-hydroxy-sn-glycero-3-PA (1-Oleoyl LPA) is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by...
| Keywords: | 1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate, 1-O-9Z-octadecenoyl-sn-glyceryl-3-phosphoric acid |
| Application: | Bioactive lipid assays |
| CAS | 65528-98-5 |
| MW: | 436.5 D |
From 45.00€
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beta-Muricholic Acid
Item number: Cay20287-1
beta-Muricholic acid (beta-MCA) is a murine-specific primary bile acid. Dietary administration of beta-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of beta-MCA also dissolves 100% of gallstones in a gallstone-susceptible...
| Keywords: | 5beta-Cholanic Acid-3alpha,6beta,7beta-triol, beta-MCA, (5beta)-3alpha,6beta,7beta-trihydroxy-cholan-24-oic acid |
| CAS | 2393-59-1 |
| MW: | 408.6 D |
From 147.00€
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alpha-Muricholic Acid
Item number: Cay20291-1
alpha-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of alpha-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma,...
| Keywords: | 5beta-Cholanic Acid-3alpha,6beta,7alpha-triol, alpha-MCA, (3alpha,5beta,6beta,7alpha)-3,6,7-trihydroxy-cholan-24-oic acid |
| CAS | 2393-58-0 |
| MW: | 408.6 D |
From 176.00€
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Arachidonic Acid (sodium salt)
Item number: Cay10006607-100
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free...
| Keywords: | Sodium Arachidonate, 5Z,8Z,11Z,14Z-eicosatetraenoic acid, monosodium salt |
| Application: | Bioactive lipid assays |
| CAS | 6610-25-9 |
| MW: | 326.5 D |
From 103.00€
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8-iso Prostaglandin E1
Item number: Cay13360-10
Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane which is found in human semen at levels of 7 µg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2alpha.Formal Name:...
| Keywords: | 8-epi PGE1, 8-iso PGE1, Ovinonic acid, 9-oxo-11alpha,15S-dihydroxy-(8beta)-prost-13E-en-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 21003-46-3 |
| MW: | 354.5 D |
From 77.00€
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