9CCN

9CCN is a cholesterol ester and oxidized anionic lipid. It has been found both intracellularly in plaque macrophages and extracellularly in atherosclerotic lesions where it acts as an 'eat-me' signal to facilitate phagocytic uptake of apoptotic debris. 9CCN has been used in the formation of lipid nanoparticles (LNPs) for the delivery of antagomiRs, chemically modified oligonucleotides that bind specifically to a particular miRNA, to macrophages in vitro and in vivo.Formal Name: (3beta)-cholest-5-en-3-ol, 3-(hydrogen nonanedioate). CAS Number: 596592-83-5. Synonyms: Cholesteryl-9-carboxynonanoate. Molecular Formula: C36H60O4. Formula Weight: 556.9. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml, PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml. SMILES: C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(CCCCCCCC(O)=O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C36H60O4/c1-25(2)12-11-13-26(3)30-18-19-31-29-17-16-27-24-28(20-22-35(27,4)32(29)21-23-36(30,31)5)40-34(39)15-10-8-6-7-9-14-33(37)38/h16,25-26,28-32H,6-15,17-24H2,1-5H3,(H,37,38)/t26-,28+,29+,30-,31+,32+,35+,36-/m1/s1. InChi Key: LSKNQPNXBZAGBW-ZTOACVCWSA-N.