98N12-5

98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.Formal Name: N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-4,7,10,13-tetraazahexadecanediamide. CAS Number: 917572-74-8. Synonyms: ND98. Molecular Formula: C81H163N9O5. Formula Weight: 1343.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 30 mg/ml. SMILES: CCCCCCCCCCCCNC(CCN(CCC(NCCCCCCCCCCCC)=O)CCN(CCNCCN(CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O)=O. InChi Code: InChI=1S/C81H163N9O5/c1-6-11-16-21-26-31-36-41-46-51-61-83-77(91)56-68-88(69-57-78(92)84-62-52-47-42-37-32-27-22-17-12-7-2)73-66-82-67-74-90(72-60-81(95)87-65-55-50-45-40-35-30-25-20-15-10-5)76-75-89(70-58-79(93)85-63-53-48-43-38-33-28-23-18-13-8-3)71-59-80(94)86-64-54-49-44-39-34-29-24-19-14-9-4/h82H,6-76H2,1-5H3,(H,83,91)(H,84,92)(H,85,93)(H,86,94)(H,87,95). InChi Key: HXVVOLDXHIMZJZ-UHFFFAOYSA-N.