80-O18

80-O18 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for use in vitro. An LNP complex containing 80-O18 and a Cre-GFP fusion protein tagged with one of three assay-specific chloroalkane tags displays high total cellular uptake and functional delivery in reporter assays using HeLa-DsRed cells, as well as cytosolic delivery in a chloroalkane penetration assay (CAPA) screen using HeLa-HGM cells.Formal Name: N-[3-(dimethylamino)propyl]-N-[3-(octadecyloxy)-3-oxopropyl]-beta-alanine, octadecyl ester. CAS Number: 1638334-27-6. Molecular Formula: C47H94N2O4. Formula Weight: 751.3. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml, PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml. SMILES: O=C(OCCCCCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCCCCCC)=O)CCCN(C)C. InChi Code: InChI=1S/C47H94N2O4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-44-52-46(50)38-42-49(41-37-40-48(3)4)43-39-47(51)53-45-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h5-45H2,1-4H3. InChi Key: LWTRCSOOEXKOHW-UHFFFAOYSA-N.