8-iso Prostaglandin F2alpha

8-iso Prostaglandin F2alpha
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16350-1 1 mg -

6 - 10 business days*

157.00€
Cay16350-5 5 mg -

6 - 10 business days*

704.00€
Cay16350-10 10 mg -

6 - 10 business days*

1,173.00€
 
8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid... more
Product information "8-iso Prostaglandin F2alpha"
8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2alpha levels are about 180-200 pg/mg of creatinine. 8-iso PGF2alpha is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2alpha inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively. Formal Name: 9alpha,11alpha,15S-trihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic acid. CAS Number: 27415-26-5. Synonyms: iPF2alpha-III, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, 8-epi PGF2alpha, 15-F2t-Isoprostane. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >99%. Formulation: A crystalline solid. Solubility: DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: 3 mg/ml. SMILES: O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,18-,19+/m0/s1. InChi Key: PXGPLTODNUVGFL-NAPLMKITSA-N.
Keywords: 15-F2t-Isoprostane, 8-epi PGF2alpha, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, iPF2alpha-III, 9alpha,11alpha,15S-trihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 16350

Properties

Application: TP receptor agonist
MW: 354.5 D
Formula: C20H34O5
Purity: >99%
Format: Crystalline Solid

Database Information

CAS : 27415-26-5| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H360
P Phrases: P201, P202, P264, P270, P280, P301+310, P308+313, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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