Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay50351-25 25 µg -

6 - 10 business days*

Cay50351-50 50 µg -

6 - 10 business days*

Cay50351-100 100 µg -

6 - 10 business days*

Cay50351-500 500 µg -

6 - 10 business days*

(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from... more
Product information "(±)8(9)-EET"
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by IL-1beta in a PPARalpha-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats. Formal Name: (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid. Synonyms: (±)8,9-EpETrE. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: >50 mg/ml (per Rao Maddipati), DMSO: >50 mg/ml (per Rao Maddipati), Ethanol: >50 mg/ml (per Rao Maddipati), PBS pH 7.2: >1 mg/ml (from 13(S)-HODE). SMILES: CCCCC/C=C\C/C=C\C[C@@H](O1)[C@@H]1C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,12-9-,13-10-/t18-,19+/m1/s1. InChi Key: DBWQSCSXHFNTMO-ZZMPYBMWSA-N.
Keywords: (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid
Supplier: Cayman Chemical
Supplier-Nr: 50351


Application: Bioactive lipid assays
MW: 320.5 D
Formula: C20H32O3
Purity: >98%
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Our products are for laboratory research use only: Not for administration to humans!
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