7-keto-25-hydroxy Cholesterol

7-keto-25-hydroxy Cholesterol is an oxysterol and a proposed metabolite of 7-keto cholesterol (Cay-16339) and 7-dehydro cholesterol (Cay-14612). It binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. It also increases EGF high affinity binding site numbers in normal rat kidney (NRK) cells.Formal Name: 3beta,25-dihydroxy-cholest-5-en-7-one. CAS Number: 64907-23-9. Molecular Formula: C27H44O3. Formula Weight: 416.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC([C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCCC(C)(O)C)C)=O. InChi Code: InChI=1S/C27H44O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-22,24,28,30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,24+,26+,27-/m1/s1. InChi Key: NQBVGGWSAXBLBE-BYJKJZODSA-N.