5-OxoETE-d7

5-OxoETE-d7 contains seven deuterium atoms at the 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5-oxoETE by GC- or LC-mass spectrometry. 5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils. It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the mitogen-activated protein kinase (MAPK) pathway in stimulated neutrophils.Formal Name: 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic-6,8,9,11,12,14,15-d7 acid. CAS Number: 1881277-29-7. Synonyms: 5-KETE-d7. Molecular Formula: C20H23D7O3. Formula Weight: 325.5. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.8 mg/ml. lambdamax: 279 nm. SMILES: CCCCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C=C([2H])\C(CCCC(O)=O)=O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/i6D,7D,9D,10D,12D,13D,16D. InChi Key: MEASLHGILYBXFO-BWRCDNCFSA-N.