4A3-SC7

4A3-SC7 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo. LNPs containing 4A3-SC7 selectively accumulate in mouse liver. LNPs containing 4A3-SC7 have been used to induce gene editing in a mouse model of alpha-1 antitrypsin deficiency. InChI: InChI=1S/C71H131N3O16S4/c1-10-14-18-22-26-52-91-56-60(5)68(79)87-48-44-83-64(75)32-40-73(41-33-65(76)84-45-49-88-69(80)61(6)57-92-53-27-23-19-15-11-2)38-30-36-72(9)37-31-39-74(42-34-66(77)85-46-50-89-70(81)62(7)58-93-54-28-24-20-16-12-3)43-35-67(78)86-47-51-90-71(82)63(8)59-94-55-29-25-21-17-13-4/h60-63H,10-59H2,1-9H3 InChIKey: YDQQWAUZFPFEIH-UHFFFAOYSA-N SMILES: O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCC)C)=O