4-O10b1
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
An ionizable cationic lipid (pKa = 5.148), LNPs containing 4-O10b1, conjugated to an anti-F4/80... more
Product information "4-O10b1"
An ionizable cationic lipid (pKa = 5.148), LNPs containing 4-O10b1, conjugated to an anti-F4/80 antibody, and encapsulating siRNA targeting the mRNA encoding Tak1 inhibit poly(I:C)-induced production of IL-1beta, IL-6, and TNF-alpha in RAW 264.7 macrophages, intranasal administration of these LNPs decreases lung injury and reduces total protein levels and Mpo activity in BALF in a mouse model of influenza A-induced pneumonia. Formulation: A solution in ethanol. InChI: InChI=1S/C62H120N4O8/c1-9-13-17-21-25-29-35-55(5)71-59(67)39-47-63(48-40-60(68)72-56(6)36-30-26-22-18-14-10-2)43-33-45-65-51-53-66(54-52-65)46-34-44-64(49-41-61(69)73-57(7)37-31-27-23-19-15-11-3)50-42-62(70)74-58(8)38-32-28-24-20-16-12-4/h55-58H,9-54H2,1-8H3. InChIKey: KGPSHYZXZZTKHI-UHFFFAOYSA-N. SMILES: CC(CCCCCCCC)OC(CCN(CCC(OC(C)CCCCCCCC)=O)CCCN1CCN(CCCN(CCC(OC(C)CCCCCCCC)=O)CCC(OC(C)CCCCCCCC)=O)CC1)=O
| Keywords: | tetra(decan-2-yl) 3,3',3'',3'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 40603 |
Properties
| Application: | Ionizable cationic lipid, LNP formation |
| Immunogen: | 1049.7 |
| MW: | 1049.7 D |
| Formula: | C62H120N4O8 |
| Purity: | >95% |
| Format: | Solution |
Database Information
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H225, H319, H333 |
| P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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