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4-Biphenylacetic acid is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of the prodrug fenbufen (Cay-28851). It inhibits prostaglandin E2 (PGE2, Cay-14010) synthesis in a cell-free assay (IC50 = 3.2 µM). In vivo, 4-biphenylacetic acid (2 mg/kg) suppresses UV-induced erythema in guinea pigs. 4-Biphenylacetic acid (16 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It decreases phenylquinone-induced writhing in mice (ED50 = 9.9 mg/kg).Formal Name: [1,1'-biphenyl]-4-acetic acid. CAS Number: 5728-52-9. Synonyms: p-Biphenylacetic Acid, Cl-83544, Felbinac, LY601017, NSC 16284. Molecular Formula: C14H12O2. Formula Weight: 212.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Methanol: Slightly soluble. SMILES: OC(CC1=CC=C(C2=CC=CC=C2)C=C1)=O. InChi Code: InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16). InChi Key: QRZAKQDHEVVFRX-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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