3-Methyladipic Acid

3-Methyladipic acid is a catabolite of the branched-chain fatty acid phytanic acid (Cay-90360), which is ingested via the diet. It is formed from phytanic acid via omega- and then beta-oxidation in patients with adult Refsum disease, a disorder characterized by high levels of phytanic acid in the blood and tissues due to a deficiency in phytanoyl-CoA hydroxylase, the enzyme that converts phytanoyl-CoA (Cay-10011499) to 2-hydroxyphytanoyl-CoA during peroxisomal beta-oxidation. Urinary levels of 3-methyladipic acid have been used as a biomarker for the omega-oxidation of phytanic acid in patients with adult Refsum disease.Formal Name: 3-methyl-hexanedioic acid. CAS Number: 3058-01-3. Synonyms: FA 7:1,O2, NSC 22069. Molecular Formula: C7H12O4. Formula Weight: 160.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 14 mg/ml, DMSO: 12 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: O=C(CCC(CC(O)=O)C)O. InChi Code: InChI=1S/C7H12O4/c1-5(4-7(10)11)2-3-6(8)9/h5H,2-4H2,1H3,(H,8,9)(H,10,11). InChi Key: SYEOWUNSTUDKGM-UHFFFAOYSA-N.