2-thio PAF

2-thio PAF is an isosteric analog of PAF. It is also a synthetic analog of PAF which contains an acetyl group attached by a thioester bond at the sn-2 position. It functions as a PAF receptor agonist, and its potency is comparable to PAF C-18 in rabbit platelet aggregation, and to PAF C-16 in the activation of guinea pig macrophages. 2-thio PAF is a substrate for lysophospholipase II and for PAF-AH, and is the substrate used in Cayman's PAF-AH Assay Kit (Cay-760901).Formal Name: 1-O-hexadecyl-2-deoxy-2-thio-S-acetyl-sn-glyceryl-3-phosphorylcholine. CAS Number: 96801-55-7. Molecular Formula: C26H54NO6PS. Formula Weight: 539.8. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >25 mg/ml, DMSO: >25 mg/ml, PBS pH 7.2: >50 mg/ml. SMILES: CCCCCCCCCCCCCCCCOC[C@@H](SC(C)=O)COP(OCC[N+](C)(C)C)([O-])=O. InChi Code: InChI=1S/C26H54NO6PS/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(35-25(2)28)24-33-34(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1. InChi Key: YPPZOKNKENLFTE-AREMUKBSSA-N.