1O14

1O14 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). 1O14-containing LNPs have been used for the delivery of IL-1beta siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury induced by LPS and galactosamine (GalN).Formal Name: 15,19,28-tris(2-hydroxytetradecyl)-15,19,24,28-tetraazadotetracontane-13,30-diol. Molecular Formula: C80H166N4O5. Formula Weight: 1264.2. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 25 mg/ml. SMILES: OC(CCCCCCCCCCCC)CN(CC(O)CCCCCCCCCCCC)CCCN(CC(O)CCCCCCCCCCCC)CCCCNCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC. InChi Code: InChI=1S/C80H166N4O5/c1-6-11-16-21-26-31-36-41-46-51-60-76(85)71-82(69-59-70-84(74-79(88)63-54-49-44-39-34-29-24-19-14-9-4)75-80(89)64-55-50-45-40-35-30-25-20-15-10-5)67-57-56-65-81-66-58-68-83(72-77(86)61-52-47-42-37-32-27-22-17-12-7-2)73-78(87)62-53-48-43-38-33-28-23-18-13-8-3/h76-81,85-89H,6-75H2,1-5H3. InChi Key: SOSDQKQICXEPKX-UHFFFAOYSA-N.