17alpha-Hydroxyprogesterone

17alpha-Hydroxyprogesterone (17-OHP) is a steroid and precursor in the synthesis of adrenal androgens. It binds to the glucocorticoid receptor in a cell-free assay (IC50 = 82 nM for the human receptor) and induces glucocorticoid receptor transactivation in HEK293 cells (EC50 = 1.2 µM). 17-OHP (0.005-1 µM) inhibits aldosterone-induced transactivation of the mineralocorticoid receptor in cell-based assays. Serum levels of 17-OHP are increased in patients with congenital adrenal hyperplasia.Formal Name: 17-hydroxy-pregn-4-ene-3,20-dione. CAS Number: 68-96-2. Synonyms: NSC 15468, 17-OHP, 17-hydroxy Progesterone. Molecular Formula: C21H30O3. Formula Weight: 330.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 241 nm. SMILES: C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)CC[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C. InChi Code: InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1. InChi Key: DBPWSSGDRRHUNT-CEGNMAFCSA-N.