16,16-dimethyl Prostaglandin A1

16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml. Formal Name: 9-oxo-15R-hydroxy-16,16-dimethyl-prosta-10,13E-dien-1-oic acid. CAS Number: 41692-24-4. Synonyms: 16,16-dimethyl PGA1. Molecular Formula: C22H36O4. Formula Weight: 364.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: >75 mg/ml (from PGA1), DMSO: >50 mg/ml (from PGA1), Ethanol: >100 mg/ml (from PGA1), PBS pH 7.2: >2.4 mg/ml (from PGA1). lambdamax: 216 nm. SMILES: CCCCC(C)(C)C(O)\C=C\[C@H]1C=CC(=O)C1CCCCCCC(=O)O. InChi Code: InChI=1S/C22H36O4/c1-4-5-16-22(2,3)20(24)15-13-17-12-14-19(23)18(17)10-8-6-7-9-11-21(25)26/h12-15,17-18,20,24H,4-11,16H2,1-3H3,(H,25,26)/b15-13+/t17-,18-,20-/m1/s1. InChi Key: CTQQHQGBBMYJPT-DZFVFWAGSA-N.