15(R)-15-methyl Prostaglandin A2

Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity. 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil. The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published.Formal Name: 9-oxo-15R-hydroxy-15-methyl-prosta-5Z,10,13E-trien-1-oic acid. CAS Number: 96440-68-5. Synonyms: 15(R)-15-methyl PGA2. Molecular Formula: C21H32O4. Formula Weight: 348.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >75 mg/ml (from PGA1), DMSO: >50 mg/ml (from PGA1), Ethanol: >100 mg/ml (from PGA1), PBS pH 7.2: >2.4 mg/ml (from PGA1). lambdamax: 216 nm. SMILES: O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@](C)(O)CCCCC)C=C1. InChi Code: InChI=1S/C21H32O4/c1-3-4-9-15-21(2,25)16-14-17-12-13-19(22)18(17)10-7-5-6-8-11-20(23)24/h5,7,12-14,16-18,25H,3-4,6,8-11,15H2,1-2H3,(H,23,24)/b7-5-,16-14+/t17-,18-,21-/m1/s1. InChi Key: UEBXYYKXJUBAJX-ULDSDQABSA-N.