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Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or... more
Product information "(±)14(15)-EET-SI"
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch. (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to beta-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries. In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.Formal Name: N-(methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide. CAS Number: 218461-97-3. Synonyms: 14,15-EpETrE-SI, 14(15)-EET-SI, 14(15)-EET-sulfonimide. Molecular Formula: C21H35NO4S. Formula Weight: 397.6. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: CCCCC[C@H]1O[C@H]1C/C=C\C/C=C\C/C=C\CCCC(=O)NS(=O)(=O)C. InChi Code: InChI=1S/C21H35NO4S/c1-3-4-13-16-19-20(26-19)17-14-11-9-7-5-6-8-10-12-15-18-21(23)22-27(2,24)25/h5,7-8,10-11,14,19-20H,3-4,6,9,12-13,15-18H2,1-2H3,(H,22,23)/b7-5-,10-8-,14-11-/t19-,20+/m1/s1. InChi Key: UPGGGACSUDOHOT-AWVFLLPBSA-N.
Keywords: | 14(15)-EET-SI, 14(15)-EET-sulfonimide, 14,15-EpETrE-SI, N-(methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10009286 |
Properties
Application: | Bioactive lipid assays |
MW: | 397.6 D |
Formula: | C21H35NO4S |
Purity: | >95% |
Format: | Solution |
Database Information
CAS : | 218461-97-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H225, H319, H336 |
P Phrases: | P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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