14(15)-EET-SI

14(15)-EET-SI
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009286-25 25 µg -

3 - 10 business days*

82.00€
Cay10009286-50 50 µg -

3 - 10 business days*

155.00€
Cay10009286-100 100 µg -

3 - 10 business days*

293.00€
 
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or... more
Product information "14(15)-EET-SI"
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch. (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to beta-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries. In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. Formal Name: N-(methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide. CAS Number: 218461-97-3. Synonyms: 14,15-EpETrE-SI, 14(15)-EET-SI, 14(15)-EET-sulfonimide. Molecular Formula: C21H35NO4S. Formula Weight: 397.6. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: CCCCC[C@H]1O[C@H]1C/C=C\C/C=C\C/C=C\CCCC(=O)NS(=O)(=O)C. InChi Code: InChI=1S/C21H35NO4S/c1-3-4-13-16-19-20(26-19)17-14-11-9-7-5-6-8-10-12-15-18-21(23)22-27(2,24)25/h5,7-8,10-11,14,19-20H,3-4,6,9,12-13,15-18H2,1-2H3,(H,22,23)/b7-5-,10-8-,14-11-/t19-,20+/m1/s1. InChi Key: UPGGGACSUDOHOT-AWVFLLPBSA-N.
Keywords: 14(15)-EET-SI, 14(15)-EET-sulfonimide, 14,15-EpETrE-SI, N-(methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide
Supplier: Cayman Chemical
Supplier-Nr: 10009286

Properties

Application: Bioactive lipid assays
MW: 397.6 D
Formula: C21H35NO4S
Purity: >95%
Format: Solution

Database Information

CAS : 218461-97-3| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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