(±)14(15)-EET

(±)14(15)-EET
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay50651-25 25 µg -

6 - 10 business days*

49.00€
Cay50651-50 50 µg -

6 - 10 business days*

88.00€
Cay50651-100 100 µg -

6 - 10 business days*

157.00€
Cay50651-500 500 µg -

6 - 10 business days*

488.00€
 
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is... more
Product information "(±)14(15)-EET"
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 µM. (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM). It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion. Formal Name: (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid. CAS Number: 197508-62-6. Synonyms: (±)14,15-EET, (±)14,15-EpETrE. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: >50 mg/ml (per Rao Maddipati), DMSO: >50 mg/ml (per Rao Maddipati), Ethanol: >50 mg/ml (per Rao Maddipati), PBS pH 7.2: >1 mg/ml (from 13(S)-HODE). SMILES: CCCCC[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O3/c1-2-3-12-15-18-19(23-18)16-13-10-8-6-4-5-7-9-11-14-17-20(21)22/h4,6-7,9-10,13,18-19H,2-3,5,8,11-12,14-17H2,1H3,(H,21,22)/b6-4-,9-7-,13-10-/t18-,19+/m1/s1. InChi Key: JBSCUHKPLGKXKH-KZTFMOQPSA-N.
Keywords: (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid
Supplier: Cayman Chemical
Supplier-Nr: 50651

Properties

Application: Bioactive lipid assays
MW: 320.5 D
Formula: C20H32O3
Purity: >98%
Format: Solution

Database Information

CAS : 197508-62-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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