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12(R)-HETE is an endogenous active metabolite of the omega-6 PUFA and eicosanoid precursor... more
Product information "12(R)-HETE"
12(R)-HETE is an endogenous active metabolite of the omega-6 PUFA and eicosanoid precursor arachidonic acid. It is formed from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) by 12R-lipoxygenase (12R-LO), as well as cytochrome P450s (CYPs). 12(R)-HETE binds to the TP receptor in washed isolated human platelets (IC50 = 0.734 µM) and inhibits platelet aggregation induced by the TP receptor agonist I-BOP (Cay-19600, IC50 = 3.6 µM). It also selectively binds to leukotriene B4 (LTB4) receptor 2 (BLT2) over BLT1 at 5 µM in CHO cell membranes expressing the human receptors. It increases the proliferation of HT-29 colon cancer cells when used at a concentration of 1 µM. 12(R)-HETE inhibits the bovine corneal Na+/K+-ATPase in a concentration-dependent manner and decreases intraocular pressure in rabbits when administered topically at doses of 1, 10, or 50 µg/eye. Intracerebroventricular administration of 12(R)-HETE (10 µg/animal) decreases LPS-induced pyresis in rats.Formal Name: 12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid. CAS Number: 82337-46-0. Synonyms: 12(R)-Hydroxyeicosatetraenoic Acid. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS pH 7.2: 0.8 mg/ml. lambdamax: 236 nm. SMILES: CCCCC/C=C\C[C@@H](O)/C=C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1. InChi Key: ZNHVWPKMFKADKW-ZYBDYUKJSA-N.
Keywords: | 12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 34560 |
Properties
Application: | Bioactive lipid assays |
MW: | 320.5 D |
Formula: | C20H32O3 |
Purity: | >98% |
Format: | Solution |
Database Information
CAS : | 82337-46-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H333 |
P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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