12-OxoETE

12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.Formal Name: 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid. CAS Number: 108437-64-5. Synonyms: 12-KETE. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS pH 7.2: 0.8 mg/ml. lambdamax: 280 nm. SMILES: CCCCC/C=C\CC(=O)/C=C\C=C\C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+. InChi Key: GURBRQGDZZKITB-VXBMJZGYSA-N.