(±)12(13)-DiHOME

(±)12(13)-DiHOME
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009832-25 25 µg -

3 - 10 business days*

32.00€
Cay10009832-50 50 µg -

3 - 10 business days*

60.00€
Cay10009832-100 100 µg -

3 - 10 business days*

113.00€
Cay10009832-500 500 µg -

3 - 10 business days*

500.00€
 
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME (Cay-52450), a cytochrome P450-derived... more
Product information "(±)12(13)-DiHOME"
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME (Cay-52450), a cytochrome P450-derived epoxide of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) also known as isoleukotoxin. It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH. Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance, increases fatty acid uptake into brown adipocytes, and decreases serum triglyceride levels in mice. Levels are also elevated in bronchoalveolar lavage fluid (BALF) in humans following exposure to biodiesel exhaust and in exhaled breath condensate in patients with allergic asthma following allergen exposure. Plasma levels of 12(13)-DiHOME are increased immediately following moderate-intensity exercise in mice and humans, an effect that can be prevented by brown adipose tissue removal in the mouse. Formal Name: 12,13-dihydroxy-9Z-octadecenoic acid. CAS Number: 263399-35-5. Synonyms: Isoleukotoxin diol. Molecular Formula: C18H34O4. Formula Weight: 314.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 µg/ml. SMILES: CCCCC[C@@H](O)[C@@H](O)C/C=C\CCCCCCCC(O)=O. InChi Code: InChI=1S/C18H34O4/c1-2-3-10-13-16(19)17(20)14-11-8-6-4-5-7-9-12-15-18(21)22/h8,11,16-17,19-20H,2-7,9-10,12-15H2,1H3,(H,21,22)/b11-8-/t16-,17+/m1/s1. InChi Key: CQSLTKIXAJTQGA-GJGKEFFFSA-N.
Keywords: Isoleukotoxin diol, 12,13-dihydroxy-9Z-octadecenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10009832

Properties

Application: Bioactive lipid assays
MW: 314.5 D
Formula: C18H34O4
Purity: >98%
Format: Solution

Database Information

CAS : 263399-35-5| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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