11beta-13,14-dihydro-15-keto Prostaglandin F2alpha-d4

11beta-13,14-dihydro-15-keto Prostaglandin F2alpha-d4 (11beta-13,14-dihydro-15-keto PGF2alpha-d4) is intended for use as an internal standard for the quantification of 11beta-13,14-dihydro-15-keto PGF2alpha (Cay-16540) by GC- or LC-MS. 11beta-13,14-dihydro-15-keto PGF2alpha is a metabolite of PGD2 (Cay-12010) in the 15-hydroxy PGDH pathway. Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11beta-PGF2alpha, as the immediate product, and 11beta-13,14-dihydro-15-keto PGF2alpha in the plasma within 10 minutes. Homogenates of human lung metabolize PGD2 first to 11beta-PGF2alpha and then to 11beta-15-keto PGF2alpha in the presence of NAD+, but not 11beta-13,14-dihydro-15-keto PGF2alpha. Guinea pig liver and kidney homogenates metabolize PGD2 to 11beta-13,14-dihydro-15-keto PGF2alpha, via 11beta-PGF2alpha, in the presence of NAD+ and NADP+.Formal Name: 9alpha,11beta-dihydroxy-15-oxo-prost-5Z-en-1-oic acid-d4. Synonyms: 11beta-13,14-dihydro-15-keto PGF2alpha-d4, 11-epi 13,14-dihydro-15-keto PGF2alpha-d4. Molecular Formula: C20H30D4O5. Formula Weight: 358.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CC([2H])([2H])C([2H])([2H])C(O)=O)[C@@H](CCC(CCCCC)=O)[C@@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19+/m1/s1/i8D2,11D2. InChi Key: VKTIONYPMSCHQI-BGUQZOOBSA-N.