11beta-13,14-dihydro-15-keto Prostaglandin F2alpha

11beta-13,14-dihydro-15-keto PGF2alpha is a metabolite of PGD2 (Cay-12010) in the 15-hydroxy PGDH pathway. Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11beta-PGF2alpha, as the immediate product, and 11beta-13,14-dihydro-15-keto PGF2alpha in the plasma within 10 minutes. Homogenates of human lung metabolize PGD2 first to 11beta-PGF2alpha and then to 11beta-15-keto-PGF2alpha in the presence of NAD+, but not 11beta-13,14-dihydro-15-keto PGF2alpha. Guinea pig liver and kidney homogenates metabolize PGD2 to 11beta-13,14-dihydro-15-keto PGF2alpha, via 11beta-PGF2alpha, in the presence of NAD+ and NADP+. Formal Name: 9alpha,11beta-dihydroxy-15-oxo-prost-5Z-en-1-oic acid. CAS Number: 107615-77-0. Synonyms: 11beta-13,14-dihydro-15-keto PGF2alpha, 11-epi-13,14-dihydro-15-keto PGF2alpha. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a), DMF: >100 mg/ml (from PGF2a), DMSO: >100 mg/ml (from PGF2a), Ethanol: >100 mg/ml (from PGF2a), PBS pH 7.2: >10 mg/ml (from PGF2a). SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19+/m1/s1. InChi Key: VKTIONYPMSCHQI-KGILNJEGSA-N.