11-deoxy Corticosterone-d8

11-deoxy Corticosterone-d8 is intended for use as an internal standard for the quantification of 11-deoxy corticosterone (Cay22916) by GC- or LC-MS. 11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland. It is a metabolite of progesterone (Cay15876) and precursor to aldosterone (Cay15273) and corticosterone (Cay16063). DOC is metabolized to the neuroactive compound (3alpha,5alpha)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats. Injections of naloxone and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys. DOC levels are increased 3.4-fold in obese and diabetic mice.. SMILES: O=C1C([2H])([2H])C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([2H])C(C([2H])([2H])O)=O)=C1[2H]. InChi Code: InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1/i3D2,7D2,11D,12D2,18D. InChi Key: ZESRJSPZRDMNHY-JRMIWGODSA-N