(±)11(12)-EET

(±)11(12)-EET
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay50511-25 25 µg -

5 - 10 business days*

45.00€
Cay50511-50 50 µg -

5 - 10 business days*

82.00€
Cay50511-100 100 µg -

5 - 10 business days*

144.00€
Cay50511-500 500 µg -

5 - 10 business days*

450.00€
 
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from... more
Product information "(±)11(12)-EET"
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET (Cay-50351), to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties. Formal Name: (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid. CAS Number: 123931-40-8. Synonyms: (±)11,12-EpETrE. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >95%. Formulation: A solution in ethanol. Solubility: DMF: >50 mg/ml (per Rao Maddipati), DMSO: >50 mg/ml (per Rao Maddipati), Ethanol: >50 mg/ml (per Rao Maddipati), PBS pH 7.2: >1 mg/ml (from 13(S)-HODE). SMILES: CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)/b8-6-,12-9-,13-10-/t18-,19+/m1/s1. InChi Key: DXOYQVHGIODESM-LZXKBWHHSA-N.
Keywords: (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid
Supplier: Cayman Chemical
Supplier-Nr: 50511

Properties

Application: Bioactive lipid assays
MW: 320.5 D
Formula: C20H32O3
Purity: >95%
Format: Solution

Database Information

CAS : 123931-40-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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