10(S),17(S)-DiHDHA

10(S),17(S)-DiHDHA
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10008128-25 25 µg -

6 - 10 business days*

185.00€
Cay10008128-50 50 µg -

6 - 10 business days*

333.00€
Cay10008128-100 100 µg -

6 - 10 business days*

629.00€
 
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived... more
Product information "10(S),17(S)-DiHDHA"
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation. Formal Name: 10(S),17(S)-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid. CAS Number: 871826-47-0. Synonyms: 10(S),17(S)-DiHDoHE, PDX, Protectin DX. Molecular Formula: C22H32O4. Formula Weight: 360.5. Purity: >98%. Formulation: A solution in ethanol. Solubility: 0.1 M Na2CO3: 1 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 270 nm. SMILES: CC/C=C\C[C@H](O)/C=C/C=C\C=C\[C@@H](O)C/C=C\C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8-,10-3-,11-6-,17-12+,18-13+/t20-,21-/m0/s1. InChi Key: CRDZYJSQHCXHEG-XLBFCUQGSA-N.
Keywords: 10(S),17(S)-DiHDoHE, PDX, Protectin DX, 10(S),17(S)-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10008128

Properties

Application: Bioactive lipid assays
MW: 360.5 D
Formula: C22H32O4
Purity: >98%
Format: Solution

Database Information

CAS : 871826-47-0| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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