1-Palmitoyl-2-hydroxy-sn-glycero-3-PC

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10172-25 25 mg -

6 - 10 business days*

49.00€
Cay10172-50 50 mg -

6 - 10 business days*

93.00€
Cay10172-100 100 mg -

6 - 10 business days*

147.00€
Cay10172-500 500 mg -

6 - 10 business days*

244.00€
 
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following... more
Product information "1-Palmitoyl-2-hydroxy-sn-glycero-3-PC"
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1beta, IL-12, and TNF-alpha in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM. It increases TGF-beta1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg. Formal Name: 1-hexadecanoyl-sn-glycerol-3-phosphorylcholine. CAS Number: 17364-16-8. Synonyms: 1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-sn-glycero-3-Phosphocholine, PC(16:0/0:0), 16:0/0:0-PC. Molecular Formula: C24H50NO7P. Formula Weight: 495.6. Purity: >98%. Formulation: A crystalline solid. Solubility: PBS (pH 7.2): 2 mg/ml. SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCC[N](C)(C)C. InChi Code: InChI=1S/C24H50NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24(27)30-21-23(26)22-32-33(28,29)31-20-19-25(2,3)4/h23,26H,5-22H2,1-4H3/t23-/m1/s1. InChi Key: ASWBNKHCZGQVJV-HSZRJFAPSA-N. Side Chain Carbon Sum: 16:0.
Keywords: 16:0/0:0-PC, 1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-sn-glycero-3-Phosphocholine, PC(16:0/0:0), 1-hexadecanoyl-sn-glycerol-3-phosphorylcholine
Supplier: Cayman Chemical
Supplier-Nr: 10172

Properties

Application: Bioactive lipid assays
MW: 495.6 D
Formula: C24H50NO7P
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 17364-16-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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