1-Linoleoyl Glycerol

Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans. 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM. 1-LG has potential application in cholesterol lowering and antiatherogenic activity. Formal Name: 9Z,12Z-octadecadienoic acid, 1-glyceryl ester. CAS Number: 2277-28-3. Synonyms: 1-LG. Molecular Formula: C21H38O4. Formula Weight: 354.5. Purity: >90%. Formulation: A solution in acetonitrile. Solubility: DMF: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(OCC(O)CO)=O. InChi Code: InChI=1S/C21H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h6-7,9-10,20,22-23H,2-5,8,11-19H2,1H3/b7-6-,10-9-. InChi Key: WECGLUPZRHILCT-HZJYTTRNSA-N. Side Chain Carbon Sum: 18:2.