1,2-Stearoyl-3-trimethylammoniumpropane (chloride)

1,2-Stearoyl-3-trimethylammoniumpropane (DSTAP) is a cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). Intraperitoneal administration of LNPs containing DSTAP and encapsulating resiquimod (R-848, Cay-14806) increases peritoneal fluid levels of IFN-alpha, the number of tumor-associated CD8+ T cells, and reduces peritoneal tumor luminescence in a CT26-luc colorectal cancer mouse model of colorectal cancer with peritoneal metastases.Formal Name: N,N,N-trimethyl-2,3-bis[(1-oxooctadecyl)oxy]-1-propanaminium, monochloride. CAS Number: 220609-41-6. Synonyms: DSTAP, 18:0 TAP. Molecular Formula: C42H84NO4 . Cl. Formula Weight: 702.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly soluble. SMILES: CCCCCCCCCCCCCCCCCC(OC(COC(CCCCCCCCCCCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]. InChi Code: InChI=1S/C42H84NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2,/h40H,6-39H2,1-5H3,1H/q+1,/p-1. InChi Key: NTTZBBIBMSBLNK-UHFFFAOYSA-M. Side Chain Carbon Sum: 18:0.