1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)

1,2-Dioleoyl-3(S)-trimethylammoniumpropane (S-DOTAP) is a cationic lipid and the less immunologically active isomer of DOTAP (Cay-15110). Lipoplexes containing S-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells. Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in S-DOTAP-containing liposomes decrease tumor size but do not induce IFN-gamma production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) in a murine cervical cancer model.Formal Name: N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monochloride. CAS Number: 428506-51-8. Synonyms: (S)-DOTAP, (S)-N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium. Molecular Formula: C42H80NO4 . Cl. Formula Weight: 698.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble, Ethanol: 20 mg/ml. SMILES: CCCCCCCC/C=C\CCCCCCCC(O[C@@H](C[N+](C)(C)C)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-]. InChi Code: InChI=1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2,/h20-23,40H,6-19,24-39H2,1-5H3,1H/q+1,/p-1/b22-20-,23-21-,/t40-,/m0./s1. InChi Key: KSXTUUUQYQYKCR-KVINLOACSA-M.