ROS Brite(TM) DHCF

ROS Brite(TM) DHCF
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-16053 1 mg -

3 - 8 business days*

230.00€
 
Ex: 560 nm. Em: 574 nm. Soluble in: DMSO. Reactive oxygen species (ROS) are chemically reactive... more
Product information "ROS Brite(TM) DHCF"
Ex: 560 nm. Em: 574 nm. Soluble in: DMSO. Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. Examples include superoxide, hydroxyl radical, singlet oxygen and peroxides. ROS is highly reactive due to the presence of unpaired valence shell electrons. ROS forms as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically. This may result in significant damage to cell structures. Cumulatively, this is known as oxidative stress. MitoROS(TM) DHCF has similar redox properties to those of 2',7'-Dichlorodihydrofluorescein diacetate with significantly red-shifted spectra. MitoROS(TM) DHCF is hydrolyzed by cellular esterases to generate the non-fluorescent reduced form that is then oxidized to generate the highly fluorescent free dye primarily by H2O2. MitoROS(TM) DHCF might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. This probe can be conveniently used to monitoring cellular redox processes for multiplexing assays with FITC-labeled antibodies or GFP cell lines. The oxidized product is highly fluorescent in cells. MitoROS(TM) DHCF provides a valuable tool for investigating oxidative stress in various pathologies.
Supplier: AAT Bioquest
Supplier-Nr: 16053

Properties

Application: Cell-based assay
MW: 701,50 D

Database Information

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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